Journal: Molecular Brain
Article Title: Altered brain connectivity in mild cognitive impairment is linked to elevated tau and phosphorylated tau, but not to GAP-43 and Amyloid-β measurements: a resting-state fMRI study
doi: 10.1186/s13041-024-01136-z
Figure Lengend Snippet: Significant linear regression plots of resting state fMRI and biomarkers. In the CN group, GAP-43 levels positively correlate with the average to posterior measure (R² = 0.25, p = 0.05). In the MCI group, T_tau and P_Tau levels negatively correlate with both cognitive measures: T_tau vs. average to posterior (R² = 0.39, p = 0.01) and average to ventral (R² = 0.32, p = 0.03), and P_Tau vs. average to posterior (R² = 0.38, p = 0.02) and average to ventral (R² = 0.33, p = 0.03). These R-squared values indicate moderate explanatory power, and the p -values show statistical significance after adjustment
Article Snippet: This ELISA employed a mouse monoclonal GAP-43 antibody (NM4) from Fujirebio (Ghent, Belgium) as the coating antibody, and a polyclonal GAP-43 antibody (ABB-135) from Nordic Biosite (Täby, Sweden) as the detector antibody, both targeting the C-terminal of GAP-43.
Techniques: